Iglesias, David A

Another surprise from Metformin: novel mechanism of action via K-Ras influences endometrial cancer response to therapy. [electronic resource] - Molecular cancer therapeutics Dec 2013 - 2847-56 p. digital

Publication Type: Journal Article; Research Support, N.I.H., Extramural; Research Support, Non-U.S. Gov't

1538-8514

10.1158/1535-7163.MCT-13-0439 doi


Animals
Antineoplastic Agents--pharmacology
Apoptosis--drug effects
Cell Line, Tumor
Cell Proliferation--drug effects
Endometrial Neoplasms--genetics
Female
Gene Silencing
Humans
Metformin--pharmacology
Mice
Mutation
PTEN Phosphohydrolase--genetics
Protein Kinase C--metabolism
Protein Transport
Proto-Oncogene Proteins--genetics
Proto-Oncogene Proteins p21(ras)
Signal Transduction--drug effects
Tumor Burden--drug effects
Xenograft Model Antitumor Assays
ras Proteins--genetics