Another surprise from Metformin: novel mechanism of action via K-Ras influences endometrial cancer response to therapy. [electronic resource]
- Molecular cancer therapeutics Dec 2013
- 2847-56 p. digital
Publication Type: Journal Article; Research Support, N.I.H., Extramural; Research Support, Non-U.S. Gov't
1538-8514
10.1158/1535-7163.MCT-13-0439 doi
Animals Antineoplastic Agents--pharmacology Apoptosis--drug effects Cell Line, Tumor Cell Proliferation--drug effects Endometrial Neoplasms--genetics Female Gene Silencing Humans Metformin--pharmacology Mice Mutation PTEN Phosphohydrolase--genetics Protein Kinase C--metabolism Protein Transport Proto-Oncogene Proteins--genetics Proto-Oncogene Proteins p21(ras) Signal Transduction--drug effects Tumor Burden--drug effects Xenograft Model Antitumor Assays ras Proteins--genetics