TY  - GEN
AU  - Goodfellow,Val S
AU  - Loweth,Colin J
AU  - Ravula,Satheesh B
AU  - Wiemann,Torsten
AU  - Nguyen,Thong
AU  - Xu,Yang
AU  - Todd,Daniel E
AU  - Sheppard,David
AU  - Pollack,Scott
AU  - Polesskaya,Oksana
AU  - Marker,Daniel F
AU  - Dewhurst,Stephen
AU  - Gelbard,Harris A
TI  - Discovery, synthesis, and characterization of an orally bioavailable, brain penetrant inhibitor of mixed lineage kinase 3
SN  - 1520-4804
PY  - 2014///0310
KW  - Administration, Oral
KW  - Animals
KW  - Area Under Curve
KW  - Biological Availability
KW  - Blood-Brain Barrier
KW  - metabolism
KW  - Brain
KW  - Carbazoles
KW  - chemical synthesis
KW  - Cells, Cultured
KW  - Cognition Disorders
KW  - complications
KW  - Drug Discovery
KW  - methods
KW  - HIV Infections
KW  - Humans
KW  - JNK Mitogen-Activated Protein Kinases
KW  - MAP Kinase Kinase Kinases
KW  - antagonists & inhibitors
KW  - Male
KW  - Mice
KW  - Mice, Inbred C57BL
KW  - Models, Chemical
KW  - Molecular Structure
KW  - Monocytes
KW  - drug effects
KW  - Phosphorylation
KW  - Protein Kinase Inhibitors
KW  - Pyridines
KW  - Pyrroles
KW  - Tumor Necrosis Factor-alpha
KW  - tat Gene Products, Human Immunodeficiency Virus
KW  - pharmacology
KW  - Mitogen-Activated Protein Kinase Kinase Kinase 11
N1  - Publication Type: Journal Article; Research Support, N.I.H., Extramural; Research Support, Non-U.S. Gov't
UR  - https://doi.org/10.1021/jm401094t
ER  -