Discovery, synthesis, and characterization of an orally bioavailable, brain penetrant inhibitor of mixed lineage kinase 3. [electronic resource]
- Journal of medicinal chemistry Oct 2013
- 8032-48 p. digital
Publication Type: Journal Article; Research Support, N.I.H., Extramural; Research Support, Non-U.S. Gov't
1520-4804
10.1021/jm401094t doi
Administration, Oral Animals Area Under Curve Biological Availability Blood-Brain Barrier--metabolism Brain--metabolism Carbazoles--chemical synthesis Cells, Cultured Cognition Disorders--complications Drug Discovery--methods HIV Infections--complications Humans JNK Mitogen-Activated Protein Kinases--metabolism MAP Kinase Kinase Kinases--antagonists & inhibitors Male Mice Mice, Inbred C57BL Models, Chemical Molecular Structure Monocytes--drug effects Phosphorylation--drug effects Protein Kinase Inhibitors--chemical synthesis Pyridines--chemical synthesis Pyrroles--chemical synthesis Tumor Necrosis Factor-alpha--metabolism tat Gene Products, Human Immunodeficiency Virus--pharmacology Mitogen-Activated Protein Kinase Kinase Kinase 11