TY  - GEN
AU  - Feiler,Christian
AU  - Fisher,Adam C
AU  - Boock,Jason T
AU  - Marrichi,Matthew J
AU  - Wright,Lori
AU  - Schmidpeter,Philipp A M
AU  - Blankenfeldt,Wulf
AU  - Pavelka,Martin
AU  - DeLisa,Matthew P
TI  - Directed evolution of Mycobacterium tuberculosis β-lactamase reveals gatekeeper residue that regulates antibiotic resistance and catalytic efficiency
SN  - 1932-6203
PY  - 2014///0408
KW  - Anti-Bacterial Agents
KW  - pharmacology
KW  - Biocatalysis
KW  - drug effects
KW  - Cell Proliferation
KW  - Clavulanic Acid
KW  - Directed Molecular Evolution
KW  - Enzyme Stability
KW  - Mutation
KW  - Mycobacterium smegmatis
KW  - Mycobacterium tuberculosis
KW  - cytology
KW  - beta-Lactam Resistance
KW  - genetics
KW  - beta-Lactamases
KW  - chemistry
N1  - Publication Type: Journal Article; Research Support, U.S. Gov't, Non-P.H.S
UR  - https://doi.org/10.1371/journal.pone.0073123
ER  -