Feiler, Christian <br/><br/>
Directed evolution of Mycobacterium tuberculosis β-lactamase reveals gatekeeper residue that regulates antibiotic resistance and catalytic efficiency.  [electronic resource] 

 -  PloS one  2013 
 - e73123 p.  digital 
<br/><br/> Publication Type: Journal Article; Research Support, U.S. Gov't, Non-P.H.S. 
<br/><br/><label>ISSN: </label>1932-6203 
<br/><br/><label>Standard No.: </label>10.1371/journal.pone.0073123  doi 
<br/><br/><label>Subjects--Topical Terms: </label><br/>Anti-Bacterial Agents--pharmacology<br/>Biocatalysis--drug effects<br/>Cell Proliferation--drug effects<br/>Clavulanic Acid--pharmacology<br/>Directed Molecular Evolution<br/>Enzyme Stability<br/>Mutation<br/>Mycobacterium smegmatis--drug effects<br/>Mycobacterium tuberculosis--cytology<br/>beta-Lactam Resistance--genetics<br/>beta-Lactamases--chemistry