Levels of target activation predict antifibrotic responses to tyrosine kinase inhibitors. [electronic resource]
- Annals of the rheumatic diseases Dec 2013
- 2039-46 p. digital
Publication Type: Journal Article
1468-2060
10.1136/annrheumdis-2013-203729 doi
Adult Animals Benzamides--therapeutic use Biopsy Bleomycin Disease Models, Animal Drug Evaluation, Preclinical--methods Female Fibrosis Fos-Related Antigen-2--genetics Humans Imatinib Mesylate Male Mice Mice, Inbred C57BL Mice, Transgenic Middle Aged Molecular Targeted Therapy--methods Piperazines--therapeutic use Protein Kinase Inhibitors--therapeutic use Protein Serine-Threonine Kinases--genetics Protein-Tyrosine Kinases--antagonists & inhibitors Proto-Oncogene Proteins c-abl--metabolism Proto-Oncogene Proteins c-sis--metabolism Pyrimidines--therapeutic use Scleroderma, Systemic--drug therapy Skin--metabolism Treatment Outcome