Cai, Xianbin

Metformin suppresses hepatocellular carcinoma cell growth through induction of cell cycle G1/G0 phase arrest and p21CIP and p27KIP expression and downregulation of cyclin D1 in vitro and in vivo. [electronic resource] - Oncology reports Nov 2013 - 2449-57 p. digital

Publication Type: Journal Article; Research Support, Non-U.S. Gov't

1791-2431

10.3892/or.2013.2718 doi


Aminoimidazole Carboxamide--analogs & derivatives
Animals
Carcinoma, Hepatocellular--drug therapy
Cell Survival--drug effects
Cyclin D1--biosynthesis
Cyclin-Dependent Kinase Inhibitor p21--biosynthesis
Cyclin-Dependent Kinase Inhibitor p27--biosynthesis
Gene Expression Regulation, Neoplastic--drug effects
Hep G2 Cells
Humans
Liver Neoplasms--drug therapy
Metformin--pharmacology
Mice
Ribonucleotides--pharmacology
Xenograft Model Antitumor Assays