Devasthale, Pratik <br/><br/>
Optimization of activity, selectivity, and liability profiles in 5-oxopyrrolopyridine DPP4 inhibitors leading to clinical candidate (Sa)-2-(3-(aminomethyl)-4-(2,4-dichlorophenyl)-2-methyl-5-oxo-5H-pyrrolo[3,4-b]pyridin-6(7H)-yl)-N,N-dimethylacetamide (BMS-767778).  [electronic resource] 

 -  Journal of medicinal chemistry  Sep 2013 
 - 7343-57 p.  digital 
<br/><br/> Publication Type: Journal Article 
<br/><br/><label>ISSN: </label>1520-4804 
<br/><br/><label>Standard No.: </label>10.1021/jm4008906  doi 
<br/><br/><label>Subjects--Topical Terms: </label><br/>Acetamides--chemical synthesis<br/>Animals<br/>Bridged Bicyclo Compounds, Heterocyclic--chemical synthesis<br/>Catalytic Domain<br/>Dipeptidyl Peptidase 4--chemistry<br/>Dipeptidyl-Peptidase IV Inhibitors--chemical synthesis<br/>Drug Design<br/>Glucose Tolerance Test<br/>Humans<br/>Male<br/>Mice<br/>Models, Molecular<br/>Pyrroles--chemical synthesis<br/>Substrate Specificity