TY  - GEN
AU  - Kirouac,Daniel C
AU  - Du,Jin Y
AU  - Lahdenranta,Johanna
AU  - Overland,Ryan
AU  - Yarar,Defne
AU  - Paragas,Violette
AU  - Pace,Emily
AU  - McDonagh,Charlotte F
AU  - Nielsen,Ulrik B
AU  - Onsum,Matthew D
TI  - Computational modeling of ERBB2-amplified breast cancer identifies combined ErbB2/3 blockade as superior to the combination of MEK and AKT inhibitors
SN  - 1937-9145
PY  - 2014///0414
KW  - Animals
KW  - Antibodies, Bispecific
KW  - Antibodies, Monoclonal, Humanized
KW  - Antineoplastic Combined Chemotherapy Protocols
KW  - pharmacology
KW  - Biomarkers, Tumor
KW  - metabolism
KW  - Breast Neoplasms
KW  - drug therapy
KW  - Computer Simulation
KW  - Feedback, Physiological
KW  - physiology
KW  - Female
KW  - Lapatinib
KW  - MAP Kinase Signaling System
KW  - drug effects
KW  - Mice
KW  - Models, Biological
KW  - Neuregulin-1
KW  - Oncogene Protein v-akt
KW  - antagonists & inhibitors
KW  - Quinazolines
KW  - Receptor, ErbB-2
KW  - Receptor, ErbB-3
KW  - Signal Transduction
KW  - Trastuzumab
N1  - Publication Type: Journal Article; Research Support, Non-U.S. Gov't
UR  - https://doi.org/10.1126/scisignal.2004008
ER  -