The relative expression of Mig6 and EGFR is associated with resistance to EGFR kinase inhibitors. [electronic resource]
- PloS one 2013
- e68966 p. digital
Publication Type: Journal Article; Research Support, N.I.H., Extramural; Research Support, Non-U.S. Gov't
1932-6203
10.1371/journal.pone.0068966 doi
Adaptor Proteins, Signal Transducing--genetics Animals Carcinoma, Non-Small-Cell Lung--drug therapy Cell Line, Tumor Drug Resistance, Neoplasm--drug effects ErbB Receptors--antagonists & inhibitors Erlotinib Hydrochloride Female Gefitinib Humans Immunoblotting Kaplan-Meier Estimate Lung--drug effects Lung Neoplasms--drug therapy Male Mice Middle Aged Phosphatidylinositol 3-Kinases--metabolism Protein Kinase Inhibitors--pharmacology Proto-Oncogene Proteins c-akt--metabolism Quinazolines--pharmacology RNA Interference Signal Transduction--drug effects Tumor Suppressor Proteins--genetics Xenograft Model Antitumor Assays