Mereniuk, Todd R

Synthetic lethal targeting of PTEN-deficient cancer cells using selective disruption of polynucleotide kinase/phosphatase. [electronic resource] - Molecular cancer therapeutics Oct 2013 - 2135-44 p. digital

Publication Type: Journal Article; Research Support, Non-U.S. Gov't

1538-8514

10.1158/1535-7163.MCT-12-1093 doi


Apoptosis--genetics
Cell Line, Tumor
DNA Breaks, Double-Stranded
DNA Repair--genetics
DNA Repair Enzymes--antagonists & inhibitors
Gene Knockout Techniques
HCT116 Cells
Humans
Molecular Targeted Therapy
Neoplasms--drug therapy
PTEN Phosphohydrolase--genetics
Phosphotransferases (Alcohol Group Acceptor)--antagonists & inhibitors
RNA, Small Interfering
Radiation Tolerance--drug effects