Synthetic lethal targeting of PTEN-deficient cancer cells using selective disruption of polynucleotide kinase/phosphatase. [electronic resource]
- Molecular cancer therapeutics Oct 2013
- 2135-44 p. digital
Publication Type: Journal Article; Research Support, Non-U.S. Gov't
1538-8514
10.1158/1535-7163.MCT-12-1093 doi
Apoptosis--genetics Cell Line, Tumor DNA Breaks, Double-Stranded DNA Repair--genetics DNA Repair Enzymes--antagonists & inhibitors Gene Knockout Techniques HCT116 Cells Humans Molecular Targeted Therapy Neoplasms--drug therapy PTEN Phosphohydrolase--genetics Phosphotransferases (Alcohol Group Acceptor)--antagonists & inhibitors RNA, Small Interfering Radiation Tolerance--drug effects