Merchant, Mark <br/><br/>
Monovalent antibody design and mechanism of action of onartuzumab, a MET antagonist with anti-tumor activity as a therapeutic agent.  [electronic resource] 

 -  Proceedings of the National Academy of Sciences of the United States of America  Aug 2013 
 - E2987-96 p.  digital 
<br/><br/> Publication Type: Journal Article; Research Support, N.I.H., Extramural; Research Support, Non-U.S. Gov't; Research Support, U.S. Gov't, Non-P.H.S. 
<br/><br/><label>ISSN: </label>1091-6490 
<br/><br/><label>Standard No.: </label>10.1073/pnas.1302725110  doi 
<br/><br/><label>Subjects--Topical Terms: </label><br/>Amino Acid Sequence<br/>Animals<br/>Antibodies, Monoclonal--chemistry<br/>Antibodies, Monoclonal, Humanized--chemistry<br/>Antineoplastic Agents--chemistry<br/>Cell Line, Tumor<br/>Cell Proliferation--drug effects<br/>Crystallography, X-Ray<br/>Drug Design<br/>Hepatocyte Growth Factor--chemistry<br/>Humans<br/>Immunoglobulin Fab Fragments--chemistry<br/>Mice<br/>Mice, Inbred BALB C<br/>Mice, Inbred C3H<br/>Mice, Nude<br/>Mice, SCID<br/>Mice, Transgenic<br/>Models, Molecular<br/>Molecular Sequence Data<br/>Neoplasms--drug therapy<br/>Protein Binding--drug effects<br/>Protein Structure, Tertiary<br/>Proto-Oncogene Proteins c-met--antagonists & inhibitors<br/>Sequence Homology, Amino Acid<br/>Xenograft Model Antitumor Assays