Association of CYP2C9*2 with bosentan-induced liver injury. [electronic resource]
- Clinical pharmacology and therapeutics Dec 2013
- 678-86 p. digital
Publication Type: Journal Article; Research Support, N.I.H., Extramural; Research Support, Non-U.S. Gov't
1532-6535
10.1038/clpt.2013.143 doi
Alanine Transaminase--metabolism Aryl Hydrocarbon Hydroxylases--genetics Aspartate Aminotransferases--metabolism Bosentan Chemical and Drug Induced Liver Injury--enzymology Cytochrome P-450 CYP2C9 Endothelin Receptor Antagonists Female Genetic Association Studies Genetic Markers HEK293 Cells Humans Hypertension, Pulmonary--drug therapy Liver-Specific Organic Anion Transporter 1 Male Middle Aged Multidrug Resistance-Associated Protein 2 Organic Anion Transporters--genetics Polymorphism, Single Nucleotide Sulfonamides--adverse effects