Zhong, Hui-ming <br/><br/>
Vorinostat, a HDAC inhibitor, showed anti-osteoarthritic activities through inhibition of iNOS and MMP expression, p38 and ERK phosphorylation and blocking NF-κB nuclear translocation.  [electronic resource] 

 -  International immunopharmacology  Oct 2013 
 - 329-35 p.  digital 
<br/><br/> Publication Type: Journal Article; Research Support, Non-U.S. Gov't 
<br/><br/><label>ISSN: </label>1878-1705 
<br/><br/><label>Standard No.: </label>10.1016/j.intimp.2013.06.027  doi 
<br/><br/><label>Subjects--Topical Terms: </label><br/>Active Transport, Cell Nucleus--drug effects<br/>Aged<br/>Cell Nucleus--metabolism<br/>Cells, Cultured<br/>Chondrocytes--drug effects<br/>Extracellular Signal-Regulated MAP Kinases--metabolism<br/>Histone Deacetylase Inhibitors--pharmacology<br/>Humans<br/>Hydroxamic Acids--pharmacology<br/>Interleukin-1beta--immunology<br/>Matrix Metalloproteinase 1--metabolism<br/>Matrix Metalloproteinase 13--metabolism<br/>Middle Aged<br/>NF-kappa B--metabolism<br/>Nitric Oxide Synthase Type II--metabolism<br/>Osteoarthritis--drug therapy<br/>Phosphorylation<br/>Signal Transduction--drug effects<br/>Tissue Inhibitor of Metalloproteinase-1--metabolism<br/>Vorinostat<br/>p38 Mitogen-Activated Protein Kinases--metabolism