TY - GEN AU - Kubas,Holger AU - Meyer,Udo AU - Krueger,Bjoern AU - Hechenberger,Mirko AU - Vanejevs,Maksims AU - Zemribo,Ronalds AU - Kauss,Valerjans AU - Ambartsumova,Raisa AU - Pyatkin,Ilya AU - Polosukhin,Alexey I AU - Abel,Ulrich TI - Discovery, synthesis, and structure-activity relationships of 2-aminoquinazoline derivatives as a novel class of metabotropic glutamate receptor 5 negative allosteric modulators SN - 1464-3405 PY - 2014///0130 KW - Allosteric Regulation KW - drug effects KW - Animals KW - Cells, Cultured KW - Drug Discovery KW - Drug Evaluation, Preclinical KW - Humans KW - Inhibitory Concentration 50 KW - Models, Molecular KW - Quinazolines KW - chemical synthesis KW - Quinazolinones KW - chemistry KW - Rats KW - Receptor, Metabotropic Glutamate 5 KW - agonists KW - Receptors, Metabotropic Glutamate KW - Structure-Activity Relationship KW - Toluidines KW - User-Computer Interface N1 - Publication Type: Journal Article UR - https://doi.org/10.1016/j.bmcl.2013.06.049 ER -