TY - GEN AU - Sceneay,Jaclyn AU - Liu,Mira C P AU - Chen,Anna AU - Wong,Christina S F AU - Bowtell,David D L AU - Möller,Andreas TI - The antioxidant N-acetylcysteine prevents HIF-1 stabilization under hypoxia in vitro but does not affect tumorigenesis in multiple breast cancer models in vivo SN - 1932-6203 PY - 2014///0205 KW - Acetylcysteine KW - pharmacology KW - Animals KW - Antineoplastic Agents KW - Antioxidants KW - Apoptosis KW - drug effects KW - Carcinogenesis KW - Cell Hypoxia KW - Cell Line, Tumor KW - Cell Proliferation KW - Drug Screening Assays, Antitumor KW - Epithelial-Mesenchymal Transition KW - Female KW - Glutathione KW - blood KW - Hypoxia-Inducible Factor 1, alpha Subunit KW - metabolism KW - Lung Neoplasms KW - blood supply KW - Mammary Neoplasms, Experimental KW - Mice KW - Mice, Inbred BALB C KW - Mice, Inbred C57BL KW - Neoplasm Transplantation KW - Neovascularization, Pathologic KW - Phenotype KW - Protein Stability KW - Tumor Burden KW - Vascular Endothelial Growth Factor A N1 - Publication Type: Journal Article; Research Support, Non-U.S. Gov't UR - https://doi.org/10.1371/journal.pone.0066388 ER -