Zhang, Yi

V8, a newly synthetic flavonoid, induces apoptosis through ROS-mediated ER stress pathway in hepatocellular carcinoma. [electronic resource] - Archives of toxicology Jan 2014 - 97-107 p. digital

Publication Type: Journal Article; Research Support, Non-U.S. Gov't

1432-0738

10.1007/s00204-013-1085-6 doi


Animals
Antineoplastic Agents--chemical synthesis
Apoptosis--drug effects
Carcinoma, Hepatocellular--drug therapy
Cell Proliferation--drug effects
Dose-Response Relationship, Drug
Endoplasmic Reticulum Chaperone BiP
Endoplasmic Reticulum Stress--drug effects
Female
Flavanones--chemistry
Flavones--chemical synthesis
Hep G2 Cells--drug effects
Humans
Inhibitory Concentration 50
Liver Neoplasms--drug therapy
Membrane Potential, Mitochondrial--drug effects
Mice
Reactive Oxygen Species--metabolism
Signal Transduction--drug effects
Transcription Factor CHOP--genetics
Xenograft Model Antitumor Assays