TY - GEN AU - Laufer,Radoslaw AU - Forrest,Bryan AU - Li,Sze-Wan AU - Liu,Yong AU - Sampson,Peter AU - Edwards,Louise AU - Lang,Yunhui AU - Awrey,Donald E AU - Mao,Guodong AU - Plotnikova,Olga AU - Leung,Genie AU - Hodgson,Richard AU - Beletskaya,Irina AU - Mason,Jacqueline M AU - Luo,Xunyi AU - Wei,Xin AU - Yao,Yi AU - Feher,Miklos AU - Ban,Fuqiang AU - Kiarash,Reza AU - Green,Erin AU - Mak,Tak W AU - Pan,Guohua AU - Pauls,Henry W TI - The discovery of PLK4 inhibitors: (E)-3-((1H-Indazol-6-yl)methylene)indolin-2-ones as novel antiproliferative agents SN - 1520-4804 PY - 2013///1111 KW - Animals KW - Antineoplastic Agents KW - chemical synthesis KW - Cell Cycle KW - drug effects KW - Cell Line, Tumor KW - Cell Proliferation KW - Drug Screening Assays, Antitumor KW - Female KW - Indazoles KW - Indoles KW - Mice KW - Mice, SCID KW - Models, Molecular KW - Protein Serine-Threonine Kinases KW - antagonists & inhibitors KW - Stereoisomerism KW - Structure-Activity Relationship KW - Transplantation, Heterologous N1 - Publication Type: Journal Article; Research Support, Non-U.S. Gov't UR - https://doi.org/10.1021/jm400380m ER -