TY  - GEN
AU  - Durmus,S
AU  - Xu,N
AU  - Sparidans,R W
AU  - Wagenaar,E
AU  - Beijnen,J H
AU  - Schinkel,A H
TI  - P-glycoprotein (MDR1/ABCB1) and breast cancer resistance protein (BCRP/ABCG2) restrict brain accumulation of the JAK1/2 inhibitor, CYT387
SN  - 1096-1186
PY  - 2014///0416
KW  - ATP Binding Cassette Transporter, Subfamily B
KW  - genetics
KW  - ATP Binding Cassette Transporter, Subfamily B, Member 1
KW  - metabolism
KW  - ATP Binding Cassette Transporter, Subfamily G, Member 2
KW  - ATP-Binding Cassette Transporters
KW  - Animals
KW  - Benzamides
KW  - blood
KW  - Brain
KW  - Cell Line
KW  - Female
KW  - Gene Deletion
KW  - Humans
KW  - Janus Kinase 1
KW  - antagonists & inhibitors
KW  - Janus Kinase 2
KW  - Janus Kinases
KW  - Mice
KW  - Neoplasm Proteins
KW  - Pyrimidines
KW  - ATP-Binding Cassette Sub-Family B Member 4
N1  - Publication Type: Journal Article; Research Support, Non-U.S. Gov't
UR  - https://doi.org/10.1016/j.phrs.2013.06.009
ER  -