TY  - GEN
AU  - Taipale,Mikko
AU  - Krykbaeva,Irina
AU  - Whitesell,Luke
AU  - Santagata,Sandro
AU  - Zhang,Jianming
AU  - Liu,Qingsong
AU  - Gray,Nathanael S
AU  - Lindquist,Susan
TI  - Chaperones as thermodynamic sensors of drug-target interactions reveal kinase inhibitor specificities in living cells
SN  - 1546-1696
PY  - 2014///0213
KW  - Animals
KW  - Cell Cycle Proteins
KW  - genetics
KW  - Crizotinib
KW  - Drug Approval
KW  - Drug Interactions
KW  - HSP90 Heat-Shock Proteins
KW  - metabolism
KW  - Humans
KW  - Mice
KW  - Molecular Chaperones
KW  - Neoplasms
KW  - drug therapy
KW  - Phosphotransferases
KW  - antagonists & inhibitors
KW  - Protein Binding
KW  - Protein Kinase Inhibitors
KW  - therapeutic use
KW  - Proto-Oncogene Proteins c-ets
KW  - Pyrazoles
KW  - Pyridines
KW  - Receptor, trkC
KW  - Repressor Proteins
KW  - Substrate Specificity
KW  - Xenograft Model Antitumor Assays
KW  - ETS Translocation Variant 6 Protein
N1  - Publication Type: Journal Article; Research Support, N.I.H., Extramural; Research Support, Non-U.S. Gov't
UR  - https://doi.org/10.1038/nbt.2620
ER  -