TY - GEN AU - Evers,Raymond AU - Dallas,Shannon AU - Dickmann,Leslie J AU - Fahmi,Odette A AU - Kenny,Jane R AU - Kraynov,Eugenia AU - Nguyen,Theresa AU - Patel,Aarti H AU - Slatter,J Greg AU - Zhang,Lei TI - Critical review of preclinical approaches to investigate cytochrome p450-mediated therapeutic protein drug-drug interactions and recommendations for best practices: a white paper SN - 1521-009X PY - 2014///0401 KW - Clinical Trials, Phase II as Topic KW - Clinical Trials, Phase III as Topic KW - Cytochrome P-450 Enzyme System KW - metabolism KW - Drug Evaluation, Preclinical KW - Drug Industry KW - Drug Interactions KW - Hepatocytes KW - drug effects KW - Humans KW - Proteins KW - pharmacology KW - United States KW - United States Food and Drug Administration N1 - Publication Type: Journal Article; Review UR - https://doi.org/10.1124/dmd.113.052225 ER -