TY - GEN AU - Visser,Michelle B AU - Sun,Chun-Xiang AU - Koh,Adeline AU - Ellen,Richard P AU - Glogauer,Michael TI - Treponema denticola major outer sheath protein impairs the cellular phosphoinositide balance that regulates neutrophil chemotaxis SN - 1932-6203 PY - 2015///0113 KW - Animals KW - Bacterial Proteins KW - isolation & purification KW - CapZ Actin Capping Protein KW - genetics KW - Cell Polarity KW - drug effects KW - Chemotactic Factors KW - pharmacology KW - Chemotaxis, Leukocyte KW - Gelsolin KW - Gene Expression Regulation KW - Male KW - Mice KW - Mice, Inbred C57BL KW - N-Formylmethionine Leucyl-Phenylalanine KW - Neuropeptides KW - Neutrophils KW - PTEN Phosphohydrolase KW - agonists KW - Phosphatidylinositol 3-Kinases KW - Phosphatidylinositol Phosphates KW - metabolism KW - Phosphoinositide-3 Kinase Inhibitors KW - Porins KW - Primary Cell Culture KW - Proto-Oncogene Proteins c-akt KW - Signal Transduction KW - Treponema denticola KW - chemistry KW - rac1 GTP-Binding Protein N1 - Publication Type: Journal Article; Research Support, Non-U.S. Gov't UR - https://doi.org/10.1371/journal.pone.0066209 ER -