TY  - GEN
AU  - Awad,Mark M
AU  - Katayama,Ryohei
AU  - McTigue,Michele
AU  - Liu,Wei
AU  - Deng,Ya-Li
AU  - Brooun,Alexei
AU  - Friboulet,Luc
AU  - Huang,Donghui
AU  - Falk,Matthew D
AU  - Timofeevski,Sergei
AU  - Wilner,Keith D
AU  - Lockerman,Elizabeth L
AU  - Khan,Tahsin M
AU  - Mahmood,Sidra
AU  - Gainor,Justin F
AU  - Digumarthy,Subba R
AU  - Stone,James R
AU  - Mino-Kenudson,Mari
AU  - Christensen,James G
AU  - Iafrate,A John
AU  - Engelman,Jeffrey A
AU  - Shaw,Alice T
TI  - Acquired resistance to crizotinib from a mutation in CD74-ROS1
SN  - 1533-4406
PY  - 2013///0628
KW  - Adenocarcinoma
KW  - drug therapy
KW  - Crizotinib
KW  - Drug Resistance
KW  - genetics
KW  - Fatal Outcome
KW  - Female
KW  - Humans
KW  - Lung Neoplasms
KW  - Middle Aged
KW  - Mutation
KW  - Protein Conformation
KW  - Protein Kinase Inhibitors
KW  - therapeutic use
KW  - Protein-Tyrosine Kinases
KW  - chemistry
KW  - Proto-Oncogene Proteins
KW  - Pyrazoles
KW  - Pyridines
KW  - Structure-Activity Relationship
KW  - Translocation, Genetic
N1  - Publication Type: Case Reports; Journal Article; Research Support, N.I.H., Extramural; Research Support, Non-U.S. Gov't
UR  - https://doi.org/10.1056/NEJMoa1215530
ER  -