Downregulation of Erbin in Her2-overexpressing breast cancer cells promotes cell migration and induces trastuzumab resistance. [electronic resource]
- Molecular immunology Nov 2013
- 104-12 p. digital
Publication Type: Journal Article; Research Support, Non-U.S. Gov't
1872-9142
10.1016/j.molimm.2013.04.007 doi
Adaptor Proteins, Signal Transducing--genetics Antibodies, Monoclonal, Humanized--pharmacology Blotting, Western Breast Neoplasms--genetics Cell Culture Techniques Cell Line Cell Line, Tumor Cell Movement--genetics Cell Survival--drug effects Dose-Response Relationship, Drug Down-Regulation Drug Resistance, Neoplasm--genetics Female Gene Expression Regulation, Neoplastic Humans Immunohistochemistry Indazoles--pharmacology MCF-7 Cells Neuregulin-1--pharmacology Phosphorylation--drug effects Proto-Oncogene Proteins c-akt--antagonists & inhibitors RNA Interference Receptor, ErbB-2--genetics Reverse Transcriptase Polymerase Chain Reaction Sulfonamides--pharmacology Trastuzumab