TY - GEN AU - Xu,Yong AU - Fang,Fang AU - Miriyala,Sumitra AU - Crooks,Peter A AU - Oberley,Terry D AU - Chaiswing,Luksana AU - Noel,Teresa AU - Holley,Aaron K AU - Zhao,Yanming AU - Kiningham,Kelley K AU - Clair,Daret K St AU - Clair,William H St TI - KEAP1 is a redox sensitive target that arbitrates the opposing radiosensitive effects of parthenolide in normal and cancer cells SN - 1538-7445 PY - 2014///0206 KW - Animals KW - Antioxidants KW - metabolism KW - Carrier Proteins KW - Cell Line KW - Cell Line, Tumor KW - Epithelial Cells KW - drug effects KW - Humans KW - Intracellular Signaling Peptides and Proteins KW - Kelch-Like ECH-Associated Protein 1 KW - Male KW - Mice KW - Mice, Nude KW - Mitochondrial Proteins KW - NF-E2-Related Factor 2 KW - Oxidation-Reduction KW - Oxidative Stress KW - Phosphoprotein Phosphatases KW - Prostatic Neoplasms KW - drug therapy KW - Radiation Tolerance KW - Radiation-Sensitizing Agents KW - pharmacology KW - Random Allocation KW - Reactive Oxygen Species KW - Sesquiterpenes KW - Thioredoxins KW - Ubiquitin KW - Xenograft Model Antitumor Assays KW - bcl-X Protein N1 - Publication Type: Journal Article; Research Support, N.I.H., Extramural; Research Support, Non-U.S. Gov't UR - https://doi.org/10.1158/0008-5472.CAN-12-4297 ER -