TY  - GEN
AU  - Ehmke,Veronika
AU  - Winkler,Edwin
AU  - Banner,David W
AU  - Haap,Wolfgang
AU  - Schweizer,W Bernd
AU  - Rottmann,Matthias
AU  - Kaiser,Marcel
AU  - Freymond,Céline
AU  - Schirmeister,Tanja
AU  - Diederich,François
TI  - Optimization of triazine nitriles as rhodesain inhibitors: structure-activity relationships, bioisosteric imidazopyridine nitriles, and X-ray crystal structure analysis with human cathepsin L
SN  - 1860-7187
PY  - 2014///0123
KW  - Cathepsin L
KW  - chemistry
KW  - Crystallography, X-Ray
KW  - Cysteine Endopeptidases
KW  - metabolism
KW  - Cysteine Proteinase Inhibitors
KW  - chemical synthesis
KW  - Dose-Response Relationship, Drug
KW  - Humans
KW  - Imidazoles
KW  - Ligands
KW  - Models, Molecular
KW  - Molecular Structure
KW  - Nitriles
KW  - Parasitic Sensitivity Tests
KW  - Pyridines
KW  - Structure-Activity Relationship
KW  - Triazines
KW  - Trypanosoma brucei brucei
KW  - drug effects
N1  - Publication Type: Journal Article; Research Support, Non-U.S. Gov't
UR  - https://doi.org/10.1002/cmdc.201300112
ER  -