Ehmke, Veronika <br/><br/>
Optimization of triazine nitriles as rhodesain inhibitors: structure-activity relationships, bioisosteric imidazopyridine nitriles, and X-ray crystal structure analysis with human cathepsin L.  [electronic resource] 

 -  ChemMedChem  Jun 2013 
 - 967-75 p.  digital 
<br/><br/> Publication Type: Journal Article; Research Support, Non-U.S. Gov't 
<br/><br/><label>ISSN: </label>1860-7187 
<br/><br/><label>Standard No.: </label>10.1002/cmdc.201300112  doi 
<br/><br/><label>Subjects--Topical Terms: </label><br/>Cathepsin L--chemistry<br/>Crystallography, X-Ray<br/>Cysteine Endopeptidases--metabolism<br/>Cysteine Proteinase Inhibitors--chemical synthesis<br/>Dose-Response Relationship, Drug<br/>Humans<br/>Imidazoles--chemical synthesis<br/>Ligands<br/>Models, Molecular<br/>Molecular Structure<br/>Nitriles--chemical synthesis<br/>Parasitic Sensitivity Tests<br/>Pyridines--chemical synthesis<br/>Structure-Activity Relationship<br/>Triazines--chemical synthesis<br/>Trypanosoma brucei brucei--drug effects