TY  - GEN
AU  - Kurokawa,Manabu
AU  - Kim,Jiyeon
AU  - Geradts,Joseph
AU  - Matsuura,Kenkyo
AU  - Liu,Liu
AU  - Ran,Xu
AU  - Xia,Wenle
AU  - Ribar,Thomas J
AU  - Henao,Ricardo
AU  - Dewhirst,Mark W
AU  - Kim,Wun-Jae
AU  - Lucas,Joseph E
AU  - Wang,Shaomeng
AU  - Spector,Neil L
AU  - Kornbluth,Sally
TI  - A network of substrates of the E3 ubiquitin ligases MDM2 and HUWE1 control apoptosis independently of p53
SN  - 1937-9145
PY  - 2013///1209
KW  - Animals
KW  - Apoptosis
KW  - Breast Neoplasms
KW  - drug therapy
KW  - Cell Line, Tumor
KW  - Drug Resistance, Neoplasm
KW  - drug effects
KW  - Female
KW  - Humans
KW  - Imidazoles
KW  - pharmacology
KW  - Immunoblotting
KW  - Lapatinib
KW  - Mice
KW  - Mice, Nude
KW  - Myeloid Cell Leukemia Sequence 1 Protein
KW  - metabolism
KW  - Nuclear Proteins
KW  - Phosphoprotein Phosphatases
KW  - Piperazines
KW  - Protein Kinase Inhibitors
KW  - Proto-Oncogene Proteins c-mdm2
KW  - antagonists & inhibitors
KW  - Quinazolines
KW  - RNA Interference
KW  - Receptor, ErbB-2
KW  - Signal Transduction
KW  - Substrate Specificity
KW  - Tumor Suppressor Protein p53
KW  - genetics
KW  - Tumor Suppressor Proteins
KW  - Ubiquitin-Protein Ligases
KW  - Xenograft Model Antitumor Assays
N1  - Publication Type: Journal Article; Research Support, N.I.H., Extramural; Research Support, Non-U.S. Gov't
UR  - https://doi.org/10.1126/scisignal.2003741
ER  -