Kurokawa, Manabu <br/><br/>
A network of substrates of the E3 ubiquitin ligases MDM2 and HUWE1 control apoptosis independently of p53.  [electronic resource] 

 -  Science signaling  May 2013 
 - ra32 p.  digital 
<br/><br/> Publication Type: Journal Article; Research Support, N.I.H., Extramural; Research Support, Non-U.S. Gov't 
<br/><br/><label>ISSN: </label>1937-9145 
<br/><br/><label>Standard No.: </label>10.1126/scisignal.2003741  doi 
<br/><br/><label>Subjects--Topical Terms: </label><br/>Animals<br/>Apoptosis<br/>Breast Neoplasms--drug therapy<br/>Cell Line, Tumor<br/>Drug Resistance, Neoplasm--drug effects<br/>Female<br/>Humans<br/>Imidazoles--pharmacology<br/>Immunoblotting<br/>Lapatinib<br/>Mice<br/>Mice, Nude<br/>Myeloid Cell Leukemia Sequence 1 Protein--metabolism<br/>Nuclear Proteins--metabolism<br/>Phosphoprotein Phosphatases--metabolism<br/>Piperazines--pharmacology<br/>Protein Kinase Inhibitors--pharmacology<br/>Proto-Oncogene Proteins c-mdm2--antagonists & inhibitors<br/>Quinazolines--pharmacology<br/>RNA Interference<br/>Receptor, ErbB-2--antagonists & inhibitors<br/>Signal Transduction--drug effects<br/>Substrate Specificity<br/>Tumor Suppressor Protein p53--genetics<br/>Tumor Suppressor Proteins<br/>Ubiquitin-Protein Ligases--genetics<br/>Xenograft Model Antitumor Assays