Phenobarbital indirectly activates the constitutive active androstane receptor (CAR) by inhibition of epidermal growth factor receptor signaling. [electronic resource]
- Science signaling May 2013
- ra31 p. digital
Publication Type: Journal Article; Research Support, N.I.H., Intramural
1937-9145
10.1126/scisignal.2003705 doi
Animals Blotting, Western Cell Line, Tumor Cells, Cultured Constitutive Androstane Receptor Epidermal Growth Factor--metabolism ErbB Receptors--chemistry GABA Modulators--metabolism Hepatocytes--drug effects Humans Male Mice Mice, Inbred C3H Models, Molecular Phenobarbital--metabolism Phosphorylation--drug effects Protein Binding--drug effects Protein Phosphatase 2--genetics Protein Structure, Tertiary RNA Interference Receptors for Activated C Kinase Receptors, Cell Surface--genetics Receptors, Cytoplasmic and Nuclear--genetics Signal Transduction--drug effects