TY  - GEN
AU  - Chaturvedula,Prasad V
AU  - Mercer,Stephen E
AU  - Pin,Sokhom S
AU  - Thalody,George
AU  - Xu,Cen
AU  - Conway,Charlie M
AU  - Keavy,Deborah
AU  - Signor,Laura
AU  - Cantor,Glenn H
AU  - Mathias,Neil
AU  - Moench,Paul
AU  - Denton,Rex
AU  - Macci,Robert
AU  - Schartman,Richard
AU  - Whiterock,Valerie
AU  - Davis,Carl
AU  - Macor,John E
AU  - Dubowchik,Gene M
TI  - Discovery of (R)-N-(3-(7-methyl-1H-indazol-5-yl)-1-(4-(1-methylpiperidin-4-yl)-1-oxopropan-2-yl)-4-(2-oxo-1,2-dihydroquinolin-3-yl)piperidine-1-carboxamide (BMS-742413): a potent human CGRP antagonist with superior safety profile for the treatment of migraine through intranasal delivery
SN  - 1464-3405
PY  - 2013///1209
KW  - Administration, Intranasal
KW  - Amides
KW  - chemistry
KW  - Animals
KW  - Caco-2 Cells
KW  - Calcitonin Gene-Related Peptide Receptor Antagonists
KW  - Callithrix
KW  - Coronary Vessels
KW  - drug effects
KW  - Drug Evaluation, Preclinical
KW  - Face
KW  - blood supply
KW  - Humans
KW  - Indazoles
KW  - Migraine Disorders
KW  - drug therapy
KW  - Quinolones
KW  - Rabbits
KW  - Rats
KW  - Receptors, Calcitonin Gene-Related Peptide
KW  - metabolism
KW  - Respiratory Mucosa
N1  - Publication Type: Journal Article
UR  - https://doi.org/10.1016/j.bmcl.2013.04.012
ER  -