TY  - GEN
AU  - Dai,Congxin
AU  - Zhang,Bo
AU  - Liu,Xiaohai
AU  - Guo,Kai
AU  - Ma,Sihai
AU  - Cai,Feng
AU  - Yang,Yakun
AU  - Yao,Yong
AU  - Feng,Ming
AU  - Bao,Xinjie
AU  - Deng,Kan
AU  - Jiao,Yonghui
AU  - Wei,Zhenqing
AU  - Junji,Wei
AU  - Xing,Bing
AU  - Lian,Wei
AU  - Wang,Renzhi
TI  - Pyrimethamine sensitizes pituitary adenomas cells to temozolomide through cathepsin B-dependent and caspase-dependent apoptotic pathways
SN  - 1097-0215
PY  - 2013///1107
KW  - Animals
KW  - Antineoplastic Agents, Alkylating
KW  - pharmacology
KW  - Apoptosis
KW  - drug effects
KW  - Caspase 3
KW  - metabolism
KW  - Caspase 7
KW  - Caspase 9
KW  - Cathepsin B
KW  - biosynthesis
KW  - Cell Cycle Checkpoints
KW  - Cell Line, Tumor
KW  - Cell Proliferation
KW  - Cytochromes c
KW  - DNA Damage
KW  - Dacarbazine
KW  - analogs & derivatives
KW  - Drug Synergism
KW  - Female
KW  - Folic Acid Antagonists
KW  - Histones
KW  - Leucovorin
KW  - Matrix Metalloproteinase 2
KW  - Matrix Metalloproteinase 9
KW  - Mice
KW  - Mice, Inbred NOD
KW  - Mice, SCID
KW  - Mitochondria
KW  - Neoplasm Invasiveness
KW  - Neoplasm Transplantation
KW  - Phosphorylation
KW  - Pituitary Neoplasms
KW  - drug therapy
KW  - Poly (ADP-Ribose) Polymerase-1
KW  - Poly(ADP-ribose) Polymerases
KW  - Proto-Oncogene Proteins c-bcl-2
KW  - Pyrimethamine
KW  - Rats
KW  - Temozolomide
KW  - Up-Regulation
KW  - Xenograft Model Antitumor Assays
KW  - bcl-2-Associated X Protein
N1  - Publication Type: Journal Article; Research Support, Non-U.S. Gov't
UR  - https://doi.org/10.1002/ijc.28199
ER  -