Dai, Congxin <br/><br/>
Pyrimethamine sensitizes pituitary adenomas cells to temozolomide through cathepsin B-dependent and caspase-dependent apoptotic pathways.  [electronic resource] 

 -  International journal of cancer  Oct 2013 
 - 1982-93 p.  digital 
<br/><br/> Publication Type: Journal Article; Research Support, Non-U.S. Gov't 
<br/><br/><label>ISSN: </label>1097-0215 
<br/><br/><label>Standard No.: </label>10.1002/ijc.28199  doi 
<br/><br/><label>Subjects--Topical Terms: </label><br/>Animals<br/>Antineoplastic Agents, Alkylating--pharmacology<br/>Apoptosis--drug effects<br/>Caspase 3--metabolism<br/>Caspase 7--metabolism<br/>Caspase 9--metabolism<br/>Cathepsin B--biosynthesis<br/>Cell Cycle Checkpoints--drug effects<br/>Cell Line, Tumor<br/>Cell Proliferation--drug effects<br/>Cytochromes c--metabolism<br/>DNA Damage<br/>Dacarbazine--analogs & derivatives<br/>Drug Synergism<br/>Female<br/>Folic Acid Antagonists--pharmacology<br/>Histones--metabolism<br/>Leucovorin--pharmacology<br/>Matrix Metalloproteinase 2--biosynthesis<br/>Matrix Metalloproteinase 9--biosynthesis<br/>Mice<br/>Mice, Inbred NOD<br/>Mice, SCID<br/>Mitochondria--drug effects<br/>Neoplasm Invasiveness<br/>Neoplasm Transplantation<br/>Phosphorylation--drug effects<br/>Pituitary Neoplasms--drug therapy<br/>Poly (ADP-Ribose) Polymerase-1<br/>Poly(ADP-ribose) Polymerases--metabolism<br/>Proto-Oncogene Proteins c-bcl-2--biosynthesis<br/>Pyrimethamine--pharmacology<br/>Rats<br/>Temozolomide<br/>Up-Regulation--drug effects<br/>Xenograft Model Antitumor Assays<br/>bcl-2-Associated X Protein--biosynthesis