TY - GEN AU - Huang,Hsuan-Ying AU - Wu,Wen-Ren AU - Wang,Yu-Hui AU - Wang,Jun-Wen AU - Fang,Fu-Min AU - Tsai,Jen-Wei AU - Li,Shau-Hsuan AU - Hung,Hsiao-Chin AU - Yu,Shih-Chen AU - Lan,Jui AU - Shiue,Yow-Ling AU - Hsing,Chung-His AU - Chen,Li-Tzong AU - Li,Chien-Feng TI - ASS1 as a novel tumor suppressor gene in myxofibrosarcomas: aberrant loss via epigenetic DNA methylation confers aggressive phenotypes, negative prognostic impact, and therapeutic relevance SN - 1557-3265 PY - 2014///0108 KW - Adult KW - Aged KW - Amino-Acid N-Acetyltransferase KW - biosynthesis KW - Animals KW - Argininosuccinate Synthase KW - deficiency KW - Cell Line, Tumor KW - Cell Movement KW - genetics KW - Cell Proliferation KW - Cell Survival KW - drug effects KW - Cluster Analysis KW - DNA Methylation KW - Female KW - Fibrosarcoma KW - drug therapy KW - G1 Phase Cell Cycle Checkpoints KW - Gene Expression Profiling KW - Gene Expression Regulation, Neoplastic KW - Gene Knockdown Techniques KW - Genes, Tumor Suppressor KW - Humans KW - Hydrolases KW - administration & dosage KW - Leiomyosarcoma KW - Male KW - Mice KW - Middle Aged KW - Neoplasm Grading KW - Neoplasm Invasiveness KW - Neoplasm Staging KW - Neovascularization, Pathologic KW - Phenotype KW - Polyethylene Glycols KW - Prognosis KW - Xenograft Model Antitumor Assays N1 - Publication Type: Journal Article; Research Support, Non-U.S. Gov't UR - https://doi.org/10.1158/1078-0432.CCR-12-2641 ER -