TY  - GEN
AU  - Kharitonenkov,Alexei
AU  - Beals,John M
AU  - Micanovic,Radmila
AU  - Strifler,Beth A
AU  - Rathnachalam,Radhakrishnan
AU  - Wroblewski,Victor J
AU  - Li,Shun
AU  - Koester,Anja
AU  - Ford,Amy M
AU  - Coskun,Tamer
AU  - Dunbar,James D
AU  - Cheng,Christine C
AU  - Frye,Christopher C
AU  - Bumol,Thomas F
AU  - Moller,David E
TI  - Rational design of a fibroblast growth factor 21-based clinical candidate, LY2405319
SN  - 1932-6203
PY  - 2013///1227
KW  - 3T3 Cells
KW  - Amino Acid Substitution
KW  - Animals
KW  - Cell Line
KW  - Drug Design
KW  - Fibroblast Growth Factors
KW  - chemistry
KW  - Gene Expression
KW  - Genetic Variation
KW  - Hep G2 Cells
KW  - Humans
KW  - Klotho Proteins
KW  - Male
KW  - Membrane Proteins
KW  - metabolism
KW  - Mice
KW  - Models, Molecular
KW  - Pichia
KW  - genetics
KW  - Protein Conformation
KW  - Protein Stability
KW  - Recombinant Proteins
KW  - Temperature
N1  - Publication Type: Journal Article
UR  - https://doi.org/10.1371/journal.pone.0058575
ER  -