An initial and rapid step of lytic granule secretion precedes microtubule organizing center polarization at the cytotoxic T lymphocyte/target cell synapse. [electronic resource]
- Proceedings of the National Academy of Sciences of the United States of America Apr 2013
- 6073-8 p. digital
Publication Type: Journal Article; Research Support, Non-U.S. Gov't
1091-6490
10.1073/pnas.1218640110 doi
Cell Polarity Centrosome--metabolism Cytoplasmic Granules--metabolism Cytotoxicity, Immunologic Flow Cytometry Humans Immunological Synapses Microscopy, Confocal Microscopy, Fluorescence Microtubule-Organizing Center--ultrastructure Microtubules--metabolism Protein Kinase C--metabolism Secretory Vesicles--metabolism Signal Transduction T-Lymphocytes, Cytotoxic--cytology Time Factors