Cho, Jae-We <br/><br/>
Downregulation of type I collagen expression in silibinin-treated human skin fibroblasts by blocking the activation of Smad2/3-dependent signaling pathways: potential therapeutic use in the chemoprevention of keloids.  [electronic resource] 

 -  International journal of molecular medicine  May 2013 
 - 1148-52 p.  digital 
<br/><br/> Publication Type: Journal Article; Research Support, Non-U.S. Gov't 
<br/><br/><label>ISSN: </label>1791-244X 
<br/><br/><label>Standard No.: </label>10.3892/ijmm.2013.1303  doi 
<br/><br/><label>Subjects--Topical Terms: </label><br/>Cell Death--drug effects<br/>Cell Nucleus--drug effects<br/>Cell Proliferation--drug effects<br/>Chemoprevention<br/>Collagen Type I--genetics<br/>Down-Regulation--drug effects<br/>Fibroblasts--drug effects<br/>Humans<br/>Keloid--drug therapy<br/>Matrix Metalloproteinases--metabolism<br/>Phosphorylation--drug effects<br/>Promoter Regions, Genetic--genetics<br/>Signal Transduction--drug effects<br/>Silybin<br/>Silymarin--pharmacology<br/>Skin--pathology<br/>Smad Proteins--metabolism<br/>Smad2 Protein--metabolism<br/>Smad3 Protein--metabolism<br/>Tissue Inhibitor of Metalloproteinase-1--metabolism<br/>Transforming Growth Factor beta1--pharmacology