TY - GEN AU - Li,Hui AU - Lui,Natalie AU - Cheng,Tiffany AU - Tseng,Hsin-Hui K AU - Yue,Dongsheng AU - Giroux-Leprieur,Etienne AU - Do,Hanh T AU - Sheng,Qing AU - Jin,Joy Q AU - Luh,Thomas W AU - Jablons,David M AU - He,Biao TI - Gli as a novel therapeutic target in malignant pleural mesothelioma SN - 1932-6203 PY - 2013///0904 KW - Aged KW - Anilides KW - pharmacology KW - Animals KW - Antineoplastic Agents KW - Cell Line, Tumor KW - Cell Proliferation KW - drug effects KW - Cell Survival KW - Down-Regulation KW - Drug Synergism KW - Female KW - Gene Expression Regulation, Neoplastic KW - Glutamates KW - Guanine KW - analogs & derivatives KW - Hedgehog Proteins KW - metabolism KW - Humans KW - Kruppel-Like Transcription Factors KW - antagonists & inhibitors KW - Male KW - Mesothelioma KW - drug therapy KW - Mice KW - Mice, Nude KW - Molecular Targeted Therapy KW - Nuclear Proteins KW - Pemetrexed KW - Pleural Neoplasms KW - Pyridines KW - RNA, Small Interfering KW - Receptors, G-Protein-Coupled KW - Signal Transduction KW - Smoothened Receptor KW - Transcription Factors KW - Xenograft Model Antitumor Assays KW - Zinc Finger Protein GLI1 KW - Zinc Finger Protein Gli2 N1 - Publication Type: Journal Article; Research Support, N.I.H., Extramural; Research Support, Non-U.S. Gov't UR - https://doi.org/10.1371/journal.pone.0057346 ER -