Impaired mitochondrial biogenesis due to dysfunctional adiponectin-AMPK-PGC-1α signaling contributing to increased vulnerability in diabetic heart. [electronic resource]
- Basic research in cardiology May 2013
- 329 p. digital
Publication Type: Journal Article; Research Support, Non-U.S. Gov't
1435-1803
10.1007/s00395-013-0329-1 doi
AMP-Activated Protein Kinases--metabolism Acetylation Adenosine Triphosphate--metabolism Adiponectin--deficiency Animals Animals, Newborn Cells, Cultured DNA, Mitochondrial--metabolism DNA-Binding Proteins--metabolism Diabetes Complications--enzymology Disease Models, Animal Electron Transport Chain Complex Proteins--metabolism Energy Metabolism High Mobility Group Proteins--metabolism Leptin--deficiency Male Mice Mice, Inbred C57BL Mice, Knockout Microscopy, Electron Mitochondria, Heart--enzymology Mitochondrial Swelling Mitochondrial Turnover Myocardial Infarction--enzymology Myocardium--enzymology Nuclear Respiratory Factor 1--metabolism Peroxisome Proliferator-Activated Receptor Gamma Coactivator 1-alpha RNA Interference RNA, Messenger--metabolism RNA-Binding Proteins--metabolism Rats Rats, Sprague-Dawley Signal Transduction Time Factors Trans-Activators--genetics Transcription Factors--metabolism Transfection