A synthetic dolastatin 10 analogue suppresses microtubule dynamics, inhibits cell proliferation, and induces apoptotic cell death. [electronic resource]
- Journal of medicinal chemistry Mar 2013
- 2235-45 p. digital
Publication Type: Journal Article; Research Support, Non-U.S. Gov't
1520-4804
10.1021/jm3009629 doi
Antineoplastic Agents--chemical synthesis Apoptosis--drug effects Caspase 3--metabolism Cell Proliferation--drug effects Colchicine--pharmacology Depsipeptides--chemical synthesis Drug Interactions Drug Resistance, Neoplasm--drug effects GTP Phosphohydrolases--metabolism HeLa Cells Humans JNK Mitogen-Activated Protein Kinases--metabolism Kinetochores--drug effects MCF-7 Cells Microtubules--drug effects Mitosis--drug effects Protein Multimerization--drug effects Protein Structure, Quaternary Tubulin--chemistry Vinblastine--pharmacology