Lin, Liang-Tzung

Cinnamaldehyde-induced apoptosis in human hepatoma PLC/PRF/5 cells involves the mitochondrial death pathway and is sensitive to inhibition by cyclosporin A and z-VAD-fmk. [electronic resource] - Anti-cancer agents in medicinal chemistry Dec 2013 - 1565-74 p. digital

Publication Type: Journal Article; Research Support, Non-U.S. Gov't

1875-5992

10.2174/18715206113139990144 doi


Acrolein--analogs & derivatives
Amino Acid Chloromethyl Ketones--pharmacology
Antineoplastic Agents, Phytogenic--pharmacology
Apoptosis--drug effects
Apoptosis Regulatory Proteins
Caspase 3--genetics
Cell Line, Tumor
Cyclosporine--pharmacology
Cytochromes c--metabolism
Gene Expression Regulation, Neoplastic
Hepatocytes--drug effects
Humans
Intracellular Signaling Peptides and Proteins--genetics
Mitochondria--drug effects
Mitochondrial Membrane Transport Proteins--genetics
Mitochondrial Permeability Transition Pore
Mitochondrial Proteins--genetics
Poly(ADP-ribose) Polymerases--genetics
Reactive Oxygen Species--metabolism
Signal Transduction
X-Linked Inhibitor of Apoptosis Protein--genetics
bcl-2-Associated X Protein--genetics