Development of targeting lonidamine liposomes that circumvent drug-resistant cancer by acting on mitochondrial signaling pathways. [electronic resource]
- Biomaterials Apr 2013
- 3366-80 p. digital
Publication Type: Journal Article; Research Support, Non-U.S. Gov't
1878-5905
10.1016/j.biomaterials.2013.01.055 doi
Adenosine Triphosphate--metabolism Animals Antineoplastic Agents--pharmacology Caspases--metabolism Cell Death--drug effects Cell Line, Tumor Cell Survival--drug effects Cytochromes c--metabolism Drug Delivery Systems Drug Resistance, Neoplasm--drug effects Enzyme Activation--drug effects Epirubicin--pharmacology Female Humans Indazoles--pharmacology Liposomes--chemistry Membrane Potential, Mitochondrial--drug effects Mice Mice, Inbred BALB C Mitochondria--drug effects Myeloid Cell Leukemia Sequence 1 Protein Neoplasms--drug therapy Proto-Oncogene Proteins c-bcl-2--metabolism Reactive Oxygen Species--metabolism Signal Transduction--drug effects Xenograft Model Antitumor Assays bcl-2-Associated X Protein--metabolism