Barbara, Joanna E <br/><br/>
Metabolism-dependent inhibition of CYP3A4 by lapatinib: evidence for formation of a metabolic intermediate complex with a nitroso/oxime metabolite formed via a nitrone intermediate.  [electronic resource] 

 -  Drug metabolism and disposition: the biological fate of chemicals  May 2013 
 - 1012-22 p.  digital 
<br/><br/> Publication Type: Journal Article 
<br/><br/><label>ISSN: </label>1521-009X 
<br/><br/><label>Standard No.: </label>10.1124/dmd.113.051151  doi 
<br/><br/><label>Subjects--Topical Terms: </label><br/>Chromatography, Liquid<br/>Cytochrome P-450 CYP3A<br/>Cytochrome P-450 CYP3A Inhibitors<br/>Enzyme Inhibitors--pharmacology<br/>Humans<br/>Lapatinib<br/>Mass Spectrometry<br/>Microsomes, Liver--metabolism<br/>Nitrogen Oxides--metabolism<br/>Oximes--metabolism<br/>Quinazolines--pharmacology