Hao, Junliang <br/><br/>
Discovery of (1R,2R)-N-(4-(6-isopropylpyridin-2-yl)-3-(2-methyl-2H-indazol-5-yl)isothiazol-5-yl)-2-methylcyclopropanecarboxamide, a potent and orally efficacious mGlu5 receptor negative allosteric modulator.  [electronic resource] 

 -  Bioorganic & medicinal chemistry letters  Mar 2013 
 - 1249-52 p.  digital 
<br/><br/> Publication Type: Journal Article 
<br/><br/><label>ISSN: </label>1464-3405 
<br/><br/><label>Standard No.: </label>10.1016/j.bmcl.2013.01.009  doi 
<br/><br/><label>Subjects--Topical Terms: </label><br/>Allosteric Regulation--drug effects<br/>Amides--chemistry<br/>Animals<br/>Behavior, Animal--drug effects<br/>Cyclopropanes--chemistry<br/>Glutamic Acid--chemistry<br/>Indazoles--chemistry<br/>Male<br/>Rats<br/>Rats, Sprague-Dawley<br/>Receptor, Metabotropic Glutamate 5--chemistry<br/>Thiazoles--chemistry