TY  - GEN
AU  - Mikami,Akiko
AU  - Ohtani,Hisakazu
AU  - Hori,Satoko
AU  - Sawada,Yasufumi
TI  - Pharmacokinetic model incorporating mechanism-based inactivation of CYP2D6 can explain both non-linear kinetics and drug interactions of paroxetine
SN  - 0946-1965
PY  - 2013///0702
KW  - Anti-Arrhythmia Agents
KW  - administration & dosage
KW  - Antidepressive Agents
KW  - Biotransformation
KW  - Chemistry, Pharmaceutical
KW  - Computer Simulation
KW  - Cytochrome P-450 CYP2D6
KW  - metabolism
KW  - Cytochrome P-450 CYP2D6 Inhibitors
KW  - Delayed-Action Preparations
KW  - Drug Dosage Calculations
KW  - Drug Interactions
KW  - Enzyme Inhibitors
KW  - Humans
KW  - Metoprolol
KW  - Models, Biological
KW  - Nonlinear Dynamics
KW  - Paroxetine
N1  - Publication Type: Journal Article
UR  - https://doi.org/10.5414/CP201798
ER  -