Mikami, Akiko <br/><br/>
Pharmacokinetic model incorporating mechanism-based inactivation of CYP2D6 can explain both non-linear kinetics and drug interactions of paroxetine.  [electronic resource] 

 -  International journal of clinical pharmacology and therapeutics  May 2013 
 - 374-82 p.  digital 
<br/><br/> Publication Type: Journal Article 
<br/><br/><label>ISSN: </label>0946-1965 
<br/><br/><label>Standard No.: </label>10.5414/CP201798  doi 
<br/><br/><label>Subjects--Topical Terms: </label><br/>Anti-Arrhythmia Agents--administration & dosage<br/>Antidepressive Agents--administration & dosage<br/>Biotransformation<br/>Chemistry, Pharmaceutical<br/>Computer Simulation<br/>Cytochrome P-450 CYP2D6--metabolism<br/>Cytochrome P-450 CYP2D6 Inhibitors<br/>Delayed-Action Preparations<br/>Drug Dosage Calculations<br/>Drug Interactions<br/>Enzyme Inhibitors--administration & dosage<br/>Humans<br/>Metoprolol--administration & dosage<br/>Models, Biological<br/>Nonlinear Dynamics<br/>Paroxetine--administration & dosage