Lee, Sang Kyu

Phosphorylation of eIF2α attenuates statin-induced apoptosis by inhibiting the stabilization and translocation of p53 to the mitochondria. [electronic resource] - International journal of oncology Mar 2013 - 810-6 p. digital

Publication Type: Journal Article; Research Support, Non-U.S. Gov't

1791-2423

10.3892/ijo.2013.1792 doi


Animals
Anthracenes--pharmacology
Anticholesteremic Agents--pharmacology
Apoptosis--drug effects
Cell Line, Tumor
Cell Survival--drug effects
Cinnamates--pharmacology
Endoplasmic Reticulum--drug effects
Endoplasmic Reticulum Chaperone BiP
Endoplasmic Reticulum Stress--drug effects
Eukaryotic Initiation Factor-2--genetics
Fibrosarcoma
Heat-Shock Proteins--biosynthesis
Hydroxymethylglutaryl-CoA Reductase Inhibitors--pharmacology
JNK Mitogen-Activated Protein Kinases--antagonists & inhibitors
Membrane Potential, Mitochondrial--drug effects
Mevalonic Acid--pharmacology
Mice
Mitochondria--drug effects
Phosphorylation
Polyisoprenyl Phosphates--pharmacology
Protein Transport--drug effects
RNA Interference
RNA, Small Interfering
Sesquiterpenes--pharmacology
Signal Transduction--drug effects
Simvastatin--pharmacology
Thiourea--analogs & derivatives
Transcription Factor CHOP--biosynthesis
Tumor Suppressor Protein p53--metabolism
bcl-2-Associated X Protein--metabolism
eIF-2 Kinase--metabolism