TY  - GEN
AU  - Shackelford,David B
AU  - Abt,Evan
AU  - Gerken,Laurie
AU  - Vasquez,Debbie S
AU  - Seki,Atsuko
AU  - Leblanc,Mathias
AU  - Wei,Liu
AU  - Fishbein,Michael C
AU  - Czernin,Johannes
AU  - Mischel,Paul S
AU  - Shaw,Reuben J
TI  - LKB1 inactivation dictates therapeutic response of non-small cell lung cancer to the metabolism drug phenformin
SN  - 1878-3686
PY  - 2013///0404
KW  - AMP-Activated Protein Kinases
KW  - genetics
KW  - Animals
KW  - Apoptosis
KW  - drug effects
KW  - Blotting, Western
KW  - Carcinoma, Non-Small-Cell Lung
KW  - drug therapy
KW  - Cell Proliferation
KW  - Cells, Cultured
KW  - Eukaryotic Initiation Factor-2
KW  - Humans
KW  - Hypoglycemic Agents
KW  - therapeutic use
KW  - Lung Neoplasms
KW  - Mice
KW  - Mice, Knockout
KW  - Mitochondria
KW  - Mutation
KW  - Phenformin
KW  - Protein Serine-Threonine Kinases
KW  - antagonists & inhibitors
KW  - Proto-Oncogene Proteins p21(ras)
KW  - physiology
KW  - RNA, Messenger
KW  - Real-Time Polymerase Chain Reaction
KW  - Reverse Transcriptase Polymerase Chain Reaction
KW  - Tumor Suppressor Protein p53
N1  - Publication Type: Journal Article; Research Support, N.I.H., Extramural; Research Support, Non-U.S. Gov't
UR  - https://doi.org/10.1016/j.ccr.2012.12.008
ER  -