BIRB796, the inhibitor of p38 mitogen-activated protein kinase, enhances the efficacy of chemotherapeutic agents in ABCB1 overexpression cells. [electronic resource]
- PloS one 2013
- e54181 p. digital
Publication Type: Journal Article; Research Support, Non-U.S. Gov't
1932-6203
10.1371/journal.pone.0054181 doi
ATP Binding Cassette Transporter, Subfamily B ATP Binding Cassette Transporter, Subfamily B, Member 1--genetics Animals Antineoplastic Agents, Phytogenic--pharmacology Blotting, Western Cell Line, Tumor Cell Survival--drug effects Drug Resistance, Multiple--drug effects Drug Resistance, Neoplasm--drug effects Drug Synergism Gene Expression Regulation, Neoplastic HEK293 Cells HL-60 Cells Humans MCF-7 Cells Mice Mice, Inbred BALB C Mice, Nude Naphthalenes--pharmacology Neoplasms--drug therapy Paclitaxel--pharmacology Protein Kinase Inhibitors--pharmacology Pyrazoles--pharmacology RNA Interference Reverse Transcriptase Polymerase Chain Reaction Xenograft Model Antitumor Assays p38 Mitogen-Activated Protein Kinases--antagonists & inhibitors