P110α-mediated constitutive PI3K signaling limits the efficacy of p110δ-selective inhibition in mantle cell lymphoma, particularly with multiple relapse. [electronic resource]
- Blood Mar 2013
- 2274-84 p. digital
Publication Type: Evaluation Study; Journal Article; Research Support, N.I.H., Extramural; Research Support, Non-U.S. Gov't
1528-0020
10.1182/blood-2012-10-460832 doi
Antineoplastic Combined Chemotherapy Protocols--pharmacology Cell Line, Tumor Class I Phosphatidylinositol 3-Kinases DNA Mutational Analysis Drug Resistance, Neoplasm--genetics Gene Expression Regulation, Enzymologic--physiology Gene Expression Regulation, Neoplastic--drug effects Humans Lymphoma, Mantle-Cell--drug therapy Phosphatidylinositol 3-Kinases--genetics Phosphoinositide-3 Kinase Inhibitors Protein Kinase Inhibitors--administration & dosage Purines--administration & dosage Quinazolinones--administration & dosage Recurrence Signal Transduction--physiology Substrate Specificity Treatment Outcome